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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
86 Results for "
Tylophora ovata (Lindl.) Hook. ex Steud.
" in MedChemExpress (MCE) Product Catalog:
Products (86)
86 Results for "Tylophora ovata (Lindl.) Hook. ex Steud." in MCE Product Catalog:
6
Category:
Cardiovascular Disease Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Disease Research Fields Indole Alkaloids
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4
4
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1
1 Cited Publications
Cat. No.: HY-N0732
CAS No.: 37905-08-1
1
1 Cited Publications
Cat. No.: HY-N2411
CAS No.: 60314-89-8
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1
1 Cited Publications
Cat. No.: HY-N6850
CAS No.: 26020-14-4
Cat. No.: HY-N5037
CAS No.: 109008-27-7
Category:
Cardiovascular Disease Aquifoliaceae Triterpenes Terpenoids Plants Disease Research Fields Tabernaemontana elegans Stapf
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MS6105 is a PROTAC degrader targeting LDHA and LDHB, with DC50 values of 38 nM and 74 nM for degrading LDHA and LDHB in PANC-1 cells, respectively, and no hook effect is observed at high concentrations. MS6105 inhibits the proliferation of pancreatic cancer cells, and no obvious toxicity is observed after intraperitoneal administration in mice. MS6105 can be used for pancreatic cancer-related research .
Cat. No.: HY-N2324
CAS No.: 13040-46-5
Synonyms: (+)-Paulownin
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Cat. No.: HY-N0476
CAS No.: 84104-71-2
Synonyms: Regelide; Abruslactone A
Category:
Triterpenes Terpenoids Celastraceae Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-161108
CAS No.: 2597167-34-3
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PROTAC Chk1 degrader-1 is a Chk1-targeting PROTAC.PROTAC Chk1 degrader-1 recruits the Cereblon E3 ligase to induce ubiquitination and proteasomal degradation of Chk1.PROTAC Chk1 degrader-1 exhibits Chk1 degradation activity in malignant melanoma cells without showing a hook effect.PROTAC Chk1 degrader-1 can be used for the research of malignant melanoma .
Cat. No.: HY-N3706
CAS No.: 15297-92-4
Category:
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Cat. No.: HY-N16598
CAS No.: 887140-17-2
Category:
Catalpa ovata G. Don Pholidota yunnanensis Rolfe Orchidaceae Phenols Polyphenols Plants Bignoniaceae Saccharides Monosaccharides
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Cat. No.: HY-N4276
CAS No.: 33464-78-7
Category:
Apocynaceae Monophenols Other Diseases Lignans Phenols Phenylpropanoids Plants Disease Research Fields Trachelospermum jasminoides (Lindl.) Lem.
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Cat. No.: HY-N9106
CAS No.: 200127-80-6
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Cat. No.: HY-119767
CAS No.: 37905-07-0
Cat. No.: HY-N4307
CAS No.: 72361-67-2
Category:
Infection Alkaloids Phenols Polyphenols Plants Lauraceae Disease Research Fields Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm.
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Cat. No.: HY-N1072
CAS No.: 37239-47-7
Category:
Terpenoids Sesquiterpenes Celastraceae Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-162331
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STING Degrader-1 (compound 2), a molecular glue, is a potent STING degrader that covalently binds to STING and E3 ligase. STING Degrader-1 exhibits a "hook effect", that degrades 75% STING protein at 10 μM, and degrades ca. 30% STING protein at 30 μM .
Cat. No.: HY-169481
CAS No.: 3027918-96-0
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AP-1 is a targeted ALK PROTAC degrader. AP-1 effectively degrades various ALK fusion/mutation forms, including degradation of NPM-ALK (DC50 = 4.6 nM) and EML4-ALK (DC50 = 357.6 nM), and exhibits a typical hook effect at high concentrations. AP-1 inhibits phosphorylation of downstream STAT3, downregulates gene expression in the JAK-STAT pathway, and kills ALK-positive tumor cells via activating the caspase-3-dependent apoptosis pathway. AP-1 shows cytotoxicity against a variety of cancer cells and possesses anti-tumor activity. AP-1 can be used in research related to non-small cell lung cancer, neuroblastoma, and anaplastic large cell lymphoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
